Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 11 0.001 0.215 0.111 0.068
biological_process el 11 0.786 0.971 0.893 0.065
biological_process ka 11 0.0 0.181 0.097 0.059
biological_process rf 11 0.001 0.215 0.111 0.068
cellular_component ct 11 0.001 0.56 0.201 0.158
cellular_component el 11 0.042 0.683 0.296 0.218
cellular_component ka 11 0.0 0.561 0.191 0.157
cellular_component rf 11 0.001 0.56 0.201 0.158
disease ct 4 0.03 0.646 0.185 0.267
disease el 4 0.343 0.802 0.59 0.188
disease ka 4 0.002 0.586 0.155 0.249
disease rf 4 0.03 0.646 0.185 0.266
genetic_interaction ct 9 0.0 0.975 0.544 0.339
genetic_interaction el 9 0.0 0.975 0.538 0.33
genetic_interaction ka 9 0.0 0.011 0.005 0.004
genetic_interaction rf 9 0.0 0.963 0.538 0.335
molecular_function ct 11 0.003 0.804 0.24 0.246
molecular_function el 11 0.143 0.876 0.448 0.28
molecular_function ka 11 0.005 0.807 0.238 0.248
molecular_function rf 11 0.003 0.804 0.24 0.246
pathway ct 11 0.001 0.793 0.396 0.299
pathway el 11 0.0 0.681 0.28 0.256
pathway ka 11 0.0 0.164 0.022 0.046
pathway rf 11 0.0 0.571 0.253 0.204
phenotype ct 4 0.006 0.647 0.301 0.295
phenotype el 4 0.231 0.769 0.462 0.198
phenotype ka 4 0.003 0.692 0.315 0.312
phenotype rf 4 0.006 0.647 0.302 0.295
protein_interaction ct 11 0.002 0.219 0.111 0.093
protein_interaction el 11 0.002 0.174 0.071 0.067
protein_interaction ka 11 0.0 0.038 0.008 0.011
protein_interaction rf 11 0.002 0.214 0.104 0.089

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 11 0.002 0.769 0.244 0.246
integration_mean_by_presence el 11 0.106 0.657 0.374 0.193
integration_mean_by_presence ka 11 0.0 0.598 0.241 0.217
integration_mean_by_presence rf 11 0.0 0.801 0.251 0.281
mean ct 11 0.0 0.715 0.194 0.234
mean el 11 0.0 0.514 0.174 0.144
mean ka 11 0.0 0.312 0.122 0.114
mean rf 11 0.0 0.345 0.123 0.125

CDF plots of non integrated kernels

CDF plots of integrated kernels